The Collaborations

Industrial Contracts :

SanofiNanoconjugués PEG-PLA pour des applications biomédicales : Libération contrôlée et Imagerie

ArkemaOrgano-catalyse de polymérisation, nouveaux polymères biodégradables pour la microélectronique

IFPNouvelles réactivités en chimie du cuivre, oligomérisation de l’éthylène

Past industrial contracts Contrats industriels antérieurs

 

Academic Collaborations :

K MiqueuDr. Karinne Miqueu, Institut Pluridisciplinaire de Recherche sur l’Environnement et les Matériaux (UMR–CNRS 5254), Université de Pau et des Pays de l’Adour
Website here
Collaborative project here

X. RibasPr. Xavi Ribas, Institut de Química Computacional i Catàlisi, Universitat de Girona Espagne
Website here

L MaronPr. L. Maron, Laboratoire de Physique et Chimie des Nanoobjets (UMR–CNRS 5215), INSA, Université Paul Sabatier
Website here
Collaborative project here

JC HiersoPr. J.-C. Hierso, Institut de Chimie Moléculaire de l’Université de Bourgogne
Website here

Dr. C. Slootweg, Vu university Amsterdam (Hollande)
Website here

G. FleuryDr. Guillaume Fleury, Laboratoire de Chimie des Polymères Organiques (UMR-CNRS 5629), Université de Bordeaux
Website here

HajimeDr. Hajime Kameo, Department of Chemistry, Graduate School of Science, Osaka City University, Japon
Website here

Past academic collaborations Collaborations académiques

Topics

1 Ambiphilic derivatives: Unusual coordination modes and Catalytic applications (G. Bouhadir)

 

Over the last decade, we have developed ambiphilic compounds combining donor (D) and acceptor (A) sites. One of our main interest has been to explore and develop the ligand behavior of these compounds towards transition metals (M). Several coordination modes have been evidenced depending on the role of the acceptor site. A particular interest has been devoted to the ability of the acceptor site (i) to coordinate the transition metal as sigma-acceptor ligand, and (ii) to interact with a metal co-ligand eventually up to its abstraction to give zwitterionic complexes in which the metal center is electrophilic. The coordination behavior and the unusual interactions (nature, strength, characteristic features …) have been assessed and rationalized by theoretical studies. Currently, we are studying new ambiphilic ligands by varying the nature of the acceptor/donor sites and the linker. In this context, we aim to take profit of the presence of the acceptor site in the coordination sphere of the metal to assist the activation of H-E (E = H, BR2, SiR3) and/or C-X (X = Cl, F, …) sigma bonds.

more information, recent publications

2 Chemistry of the coinage metals (G. Szaloki)

 

Métaux du groupe 11

Our research program on coinage metal chemistry aims to gain a profound knowledge on the coordination chemistry and reactivity of these metals, in particular gold. We seek to design and develop new well-defined gold(I) and gold(III) complexes for applications in organic synthesis and materials. Homogeneous gold catalysis has developed very rapidly over the last decades, to the extent that gold complexes initially considered as inert species are now among the most efficient catalytic systems in organic synthesis. Consequently, an increasing interest was directed towards the understanding of the fundamental reactivity of gold complexes. However, in most of gold catalyzed processes developed to date, gold is used as a simple Lewis acidic catalyst for electrophilic activation of p-CC bonds. In striking contrast with the rich reactivity patterns of the other transition metals, very little is known about the reactivity of gold complexes towards important elementary steps in transition metal catalysis. We are particularly interested in investigating the reactivity of gold complexes towards oxidative addition/reductive elimination and migratory insertion processes. Thanks to a rational ligand design approach we recently evidenced that gold is able to promote unprecedented transformations such as oxidative addition of Si-Si, C-C and Csp2-X bonds, and migratory insertion of alkynes, allenes and alkenes. These common elementary steps are common with most transition metals, but were unprecedented with gold.

 

more information, recent publications

3 Pincer complexes, Non-innocent ligands and Cooperative catalysis (B. Martin-Vaca, J. Monot)

 

Pince 1

Over the last decade, pincer complexes have attracted an upsurge of interest from the scientific community. Tuning the structure of the pincer ligands has given rise to a huge variety of complexes, from which those promoting original catalytic transformations involving metal/ligand cooperation can be highlighted. In this context, we have developed an original family based on the indene skeleton which can adopt for the first time a planar h1-coordination. The central C2-M bond is a single s bond and the p contribution is very weak. The presence of an important electronic density over the indenyl backbone, especially on C1 and C3, suggests a potential participation of the ligand during some chemical transformations. Indeed, these ligands exhibit a non-innocent character demonstrated by their participation in the stoichiometric activation of organic and metallic electrophilic partners. This non-innocent character has then been successfully applied in metal/ligand cooperative catalysis. The cycloisomerization of alkynoic acids and alkynylamides takes place in the presence of palladium indenediide complexes without involvement of an external base. Recently, the group described another family of pincer ligands, namely diphosphine/phosphide oxides. Remarkably, the coordination of the two phosphine arms promotes the activation of central P(O)-C/H bonds. These oxidative additions involves only low activation barriers and directly lead to the corresponding PP(O)P pincer complexes.

more information, recent publications

4 Biodegradables polymers : synthesis and applications (B. Martin-Vaca)

 

Polymer

Polyester and polycarbonate synthetic biodegradable polymers have attracted considerable interest over the last decades not only for the encapsulation and sustained release of drugs but also for packaging and applications as additives. Among the preparation process of these polymers, the ring-opening polymerization (ROP) of lactones or cyclic carbonates allows good control of the polymer structure. In this context, we are developing new tools as well as original and efficient technics for the controlled preparation of well-defined biodegradable polymers under mild conditions. Our work combines different aspects: (i) the development of new organic and/or metallic catalytic systems, including dual organic/metallic catalytic systems, (ii) the synthesis of functionalized monomers, (iii) the preparation of (co)polymer of controlled architectures. From an application standpoint, we are searching to take profit of new copolymers for the formulation of bioactive ingredients and as nano-structured materials for microelectronics.

We demonstrated the efficiency of sulfonic, phosphoric and phosphoramidic acids for the controlled polymerization of lactide, e-caprolactone and trimethylene carbonate. In addition, we have recently succeeded in the development of a new catalytic system combining an amine and a Lewis acid for the synthesis of cyclic polyesters. Besides the applications, we are very interested in understanding the mode of action of the new catalysts and the polymerization mechanism.

 

more information, recent publications

The offers LBPB

 

If you are interested by a postdoctoral position in our group, please send a cover letter, a curriculum vitae with at least two references.

We regularly support the application for Marie Curie Sklodowska Curie and Alexander von Humbolt foundation postdoctoral fellowship.

Undergraduate student (M2, M1, L3…) are also welcome to contact us for research internship within our group.

Two offers are currently available in our team (you can download the proposals in pdf format)

  • Gold Catalysis Under Ligand Control 
  • Pincer complexes: Non-innocent Ligands and Cooperative Catalysis

Fellows

Present members

Didier Bourissou
Didier BOURISSOU
DR, CNRS
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+33 (0)5 6155 6803
CV  Publi  Conf

Blanca Martin-Vaca
Blanca MARTIN-VACA
Pr UPS
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+33 (0)5 6155 7737
CV

Ghenwa Bouhadir
Ghenwa BOUHADIR
MdC UPS
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+33 (0)5 6155 7741
CV

Julien Monot
Julien MONOT
MdC UPS
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+33 (0)5 6155 7737
CV

György SZALOKI
György SZALOKI
CR CNRS
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+33 (0)5 6155 7741
CV

Post-Doc

Navarro
Miquel NAVARRO
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+33 (0)5 6155 8722

Marelli
Enrico MARELLI
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+33 (0)5 6155 6298

Rodriguez
Jessica RODRIGUEZ VILLAR
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+33 (0)5 6155 8722

Ph'D


Charlie Blons
Charlie BLONS
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+33 (0)5 6155 8722

Maxime Boudjelel
Maxime BOUDJELEL
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+33 (0)5 6155 8722

Paul Brunel
Paul BRUNEL
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+33 (0)5 6155 6298

Arnaud CLERC
Arnaud CLERC
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+33 (0)5 6155 8722

Duval
Maryne DUVAL
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+33 (0)5 6155 8722

Mathilde RIGOULET
Mathilde RIGOULET
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+33 (0)5 6155 8722

Theulier
Cyril THEULIER
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+33 (0)5 6155 6298

Somprosong
Somprasong THONGKAM
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+33 (0)5 6155 6298

Trainee


Deidrah Carrillo
Deidrah CARRILLO
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+33 (0)5 6155 6298

Alberto TOLEDO
Alberto TOLEDO PEREZ
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+33 (0)5 6155 8722

UNGPITTAGUL Thasanaporn
Thasanaporn UNGPITTAGUL
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+33 (0)5 6155 6298

The elders Les anciens

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