Bandeau LBPB

Pincer complexes, Non-innocent ligands and Cooperative catalysis

  • Valorization of CO2: Preparation of 2-​Oxazolidinones by Metal-​Ligand Cooperative Catalysis with SCS Indenediide Pd Complexes
    P. Brunel, J. Monot, C. E. Kefalidis, L. Maron, B. Martin-Vaca,* D. Bourissou*
    ACS Catal. 2017, 7, 2652-2660.

    ACS 2017
    The capture and utilization of CO2 to prepare high-value compounds is very attractive chemically and highly desirable socially. Indenediide-based Pd SCS pincer complexes are shown here to promote the carboxylative cyclization of propargylamines leading to 2-oxazolidinones under mild conditions (0.5–1 bar of CO2, DMSO, 40–80 °C, 1–5 mol % Pd loading). The indenediide Pd complex is competitive with known catalysts. It proved successful for a wide range of propargylamines, including hitherto challenging substrates such as secondary propargylamines bearing tertiary alkyl groups at nitrogen, primary propargylamines, and propargylanilines. Thorough experimental (NMR) and computational (DFT) investigations were undertaken to gain mechanistic insights. Accordingly, (i) the resting state of the catalytic cycle is a Pd DMSO complex; (ii) the indenediide backbone and Pd center act in concert to activate the carbamic acid intermediate and promote its cyclization; (iii) proton shuttling is essential to lower the activation barriers of the initial amine carboxylation as well as of the proton transfers between the ligand backbone and the organic fragments at Pd.

  • Efficient Synthesis of Unsaturated δ- and ε-Lactones/Lactams by Catalytic Cycloisomerization: When Pt Outperforms Pd
    Ke, N. Á. Espinosa, S. Mallet-Ladeira, J. Monot, B. Martin-Vaca*, D. Bourissou*
    Adv. Synt. Catal. 2016, 358, 2324-2331.

    ASC 2016 Platine

    Platinum pincer complexes featuring an SCS indenediide backbone have been prepared and evaluated in the catalytic cycloisomerization of alkynoic acids and N-tosyl alkynylamides. One of the platinum complexes significantly outperforms its palladium analogue for the formation of 6- and 7-membered rings. The catalytic system takes advantage of the alkynophilicity of Pt and of the non-innocent character of the indenediide framework. Like for Pd, the catalytic performance is significantly improved by using an H-bond donor additive such as pyrogallol. For the first time, a large variety of ω-unsaturated δ- and ε-lactones/lactams could be prepared with high selectivities and in very good yields.

  • A case study of proton shuttling in palladium catalysis
    Monot, P. Brunel, C. E. Kefalidis, N. Á. Espinosa-Jalapa, L. Maron*, B. Martin-Vaca*, D. Bourissou*
    Chem. Sci., 2016, 7, 2179-2187.

    Chemical Science 2016

    The mechanism of alkynoic acid cycloisomerization with SCS indenediide Pd pincer complexes has been investigated experimentally and computationally. These studies confirmed the cooperation between the Pd center and the backbone of the pincer ligand, and revealed the involvement of a second molecule of substrate. It acts as a proton shuttle in the activation of the acid, it directs the nucleophilic attack of the carboxylic acid on the π-coordinated alkyne and it relays the protonolysis of the resulting vinyl Pd species. A variety of H-bond donors have been evaluated as external additives, and polyols featuring proximal hydroxyl groups, in particular catechol derivatives, led to significant catalytic enhancement. The impact of 4-nitrocatechol and 1,2,3-benzenetriol is particularly striking on challenging substrates such as internal 4- and 5-alkynoic acids. Endo/exo selectivities up to 7.3/1 and 60-fold increase in reactivity were achieved.

  • Enhanced Catalytic Performance of Indenediide Palladium Pincer Complexes for Cycloisomerization: Efficient Synthesis of Alkylidene Lactams
    N. Á. Espinosa-Jalapa, D. Ke, N. Nebra, L. Le Goanvic, S. Mallet-Ladeira, J. Monot, B. Martin-Vaca,* D. Bourissou*
    ACS Catalysis, 2014, 4, 3605-3611.

    Pincer-5

    New SCS Pd pincer complexes featuring a non-innocent indenediide backbone show high catalytic activity in cycloisomerization. A variety of alkylidene lactams (5 to 7 membered rings) have been prepared efficiently from N-tosyl alkynylamides and good results have also been obtained with challenging alkynoic acids.

  • Metal–Ligand Cooperation in the Cycloisomerization of Alkynoic Acids with Indenediide Palladium Pincer Complexes
    N. Nebra , J. Monot , R. Shaw , B. Martin-Vaca,* D. Bourissou *
    ACS Catalysis, 2013, 3, 2930-2934.

    Pincer-4

    Indenediide Pd complexes 1a-c are shown to very efficiently catalyze the cycloisomerization of alkynoic acids into alkylidene lactones via metal-ligand cooperation (TON up to 2000). 1a-c are competent towards a broad range of alkynoic acids, including functionalized and internal ones, and give access to 5- as well as 6- and 7-membered lactones in excellent yields and with very high selectivities.

  • Selected publications:

    Enhanced Catalytic Performance of Indenediide Palladium Pincer Complexes for Cycloisomerization: Efficient Synthesis of Alkylidene Lactams.
    N. Á. Espinosa-Jalapa, D. Ke, N. Nebra, L. Le Goanvic, S. Mallet-Ladeira, J. Monot, B. Martin-Vaca,* D. Bourissou*
    ACS Catalysis 2014, 4, 3605-3611.

    Metal-Ligand Cooperation in the Cycloisomerization of Alkynoic Acids with Indenediide Palladium Pincer Complexes.
    Nebra, N.; Monot, J.; Shaw, R.; Martin-Vaca, B.;* Bourissou, D.*
    ACS Catalysis 2013, 3, 2930-2934.

    Influence of the Ligand Backbone in Pincer Complexes: Indenediide-, Indolyl-, and Indenyl-Based SCS Palladium Complexes.
    Lisena, J.; Monot, J.; Mallet-Ladeira, S.; Martin-Vaca, B.;* Bourissou, D.*
    Organometallics 2013, 32, 4301-4305.

    Walking Metals in d8…d8 Hetero-bimetallic Complexes: An Original Dynamic Phenomenon
    Nebra, N.; Ladeira, S.; Maron, L.; Martin-Vaca, B.;* Bourissou, D*
    Chem. Eur. J. 2012, 18, 8474-8481.

    The 2-indenylidene chloropalladate {PdCl[Ind(Ph2P:S)2]}(nBu4N): a versatile pincer complex with "innocent" and "noninnocent" behavior.
    Oulie, P.; Nebra, N.; Ladeira, S.; Martin-Vaca, B.;* Bourissou, D.*
    Organometallics 2011, 30, 6416-6422.

    Original palladium pincer complexes deriving from 1,3-bis(thiophosphinoyl)indene proligands: Csp3-H versus Csp2-H bond activation.
    Nebra, N.; Lisena, J.; Saffon, N.; Maron, L.;* Martin-Vaca, B.;* Bourissou, D.*
    Dalton Trans. 2011, 40, 8912-8921.

    1,3-Bis(thiophosphinoyl)indene : A unique and Versatile Scaffold for Original Polymetallic Complexes
    Nebra, N.; Saffon, N.; Maron, L.;* Martin-Vaca, B.;* Bourissou, D.*
    Inorg. Chem. 2011, 50, 6378-6383.

    2-Indenylidene Pincer Complexes of Zirconium and Palladium
    Oulie, P.; Nebra, N.; Saffon, N.; Maron, L.;* Martin-Vaca, B.;* Bourissou, D.*
    J. Am. Chem. Soc. 2009, 131, 3493-3498.

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